TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma.
Yafan ChenZhengyang HanLe ZhangCaihong GaoJingyi WeiXuyuan YangYabing HanYunbo LiChunmei ZhangYixin WeiJiaqi DongWenxing XunWeifu SunTaotao ZhangHui ZhangJingtao ChenPeng YuanPublished in: Journal of translational medicine (2024)
TIMELESS exacerbates OSCC progression by modulating cellular proliferation and metabolic pathways, specifically by enhancing glycolysis and reducing oxidative phosphorylation, largely mediated through the SIRT1 pathway. This highlights TIMELESS as a potential target for OSCC therapeutic strategies.