Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals.

Yong ZhangSejal SharmaShirisha JonnalagaddaShikha KumariAarfa QueenShiva Hadi EsfahaniSabrina Rahman ArchieSaeideh NozohouriDhavalkumar PatelPaul C TrippierVardan T KaramyanThomas J Abbruscato

Published in: Pharmaceutical research (2023)

This study provides essential details about the pharmacokinetic properties of a new generation of potent non-peptidomimetic Nln activators with high BBB permeability and warrants the future development of these agents as potential neuroprotective pharmaceutics for stroke treatment.

Keyphrases

blood brain barrier
cerebral ischemia
atrial fibrillation
small molecule
endothelial cells
high throughput
climate change
combination therapy