APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort.
Sandra WeintraubMerilee TeylanBenjamin RaderKwun C G ChanMark BollenbeckWalter A KukullChristina CoventryEmily J RogalskiEileen H BigioM-Marsel MesulamPublished in: Neurology (2019)
The proportion of APOE ε4 carriers was elevated in amnestic but not aphasic manifestations of AD. These results suggest that APOE ε4 is an anatomically selective risk factor that preferentially increases the vulnerability to AD pathology of memory-related medial temporal areas rather than language-related neocortices.