The cycle effect quantified: reduced tumour uptake in subsequent cycles of [ 177 Lu]Lu-HA-DOTATATE during peptide receptor radionuclide therapy.
Hinke SiebingaJ J M A HendrikxD M V de Vries-HuizingA D R HuitemaB J de Wit-van der VeenPublished in: European journal of nuclear medicine and molecular imaging (2023)
Using a population PK modelling approach, the cycle effect of reduced tumour uptake in subsequent PRRT cycles was quantified. Our findings implied that downregulation of target receptors is probably not the major cause of the cycle effect, due to a plateau in the decrease of tumour uptake in the fourth cycle.