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Deep Morphology Learning Enhances Ex Vivo Drug Profiling-Based Precision Medicine.

Tim HeinemannChristoph KornauthYannik SeverinGregory I VladimerTea PemovskaEmir HadzijusufovicHermine AgisMaria-Theresa KrauthWolfgang R SperrPeter ValentUlrich JägerIngrid Simonitsch-KluppGiulio Superti-FurgaPhilipp Bernhard StaberBerend Snijder
Published in: Blood cancer discovery (2022)
We have recently demonstrated that image-based drug screening in patient samples identifies effective treatment options for patients with advanced blood cancers. Here we show that using deep learning to identify malignant and nonmalignant cells by morphology improves such screens. The presented workflow is robust, automatable, and compatible with clinical routine. This article is highlighted in the In This Issue feature, p. 476.
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