Identification of novel differentially expressed genes in retinas of STZ-induced long-term diabetic rats through RNA sequencing.
Xindan XingYan JiangHanying WangYuan ZhangTian NiuYuan QuChingyi WangHaiyan WangKun LiuPublished in: Molecular genetics & genomic medicine (2020)
A total of 118 DEGs were identified, of which 72 were up-regulated and 46 were down-regulated. The enriched GO terms showed that 3 most significant enrichment terms were binding (molecular function), cell part (cellular component), and biological regulation (biological process). The results of the KEGG pathway analysis revealed a significant enrichment in cell adhesion molecules, PI3K-Akt signaling pathway, and allograft rejection, etc. CONCLUSION: Our research has identified specific DEGs and also speculated their potential functions, which will provide novel targets to explore the molecular mechanisms of DR.
Keyphrases
- diabetic rats
- pi k akt
- signaling pathway
- single cell
- cell adhesion
- oxidative stress
- cell cycle arrest
- cell proliferation
- bioinformatics analysis
- transcription factor
- induced apoptosis
- epithelial mesenchymal transition
- genome wide
- cell therapy
- stem cells
- editorial comment
- kidney transplantation
- bone marrow
- gene expression
- cell death
- risk assessment
- endothelial cells
- high glucose