Analysis of genetic variants of frequently mutated genes in human papillomavirus-negative primary head and neck squamous cell carcinoma, resection margins, local recurrences and corresponding circulating cell-free DNA.

Susanne FlachJörg KumbrinkChristoph WalzJulia HessGuido DrexlerClaus BelkaMartin CanisAndreas JungPhilipp Baumeister

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2022)

Molecular profiling of cell-free DNA and resection margins has potential applications in clinical practice to guide future treatment decisions.

Keyphrases

clinical practice
single cell
current status
gene expression
dna methylation
single molecule
transcription factor
replacement therapy