Activation of ETAR and ETBR in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis.

Peng YangYujing WuFangfei LiJiangfeng TangZhenzhong ZhengQingshan Tian

Published in: BMC cardiovascular disorders (2024)

ET-1, ETAR, and ETBR were activated in both EAM-induced acute heart failure and chronic heart failure. ETAR may positively regulate EAM-induced heart failure by promoting myocardial inflammatory injury, whereas ETBR negatively regulates EAM-induced heart failure by alleviating myocardial inflammatory injury.

Keyphrases

heart failure
acute heart failure
left ventricular
high glucose
diabetic rats
drug induced
oxidative stress
atrial fibrillation
endothelial cells
cardiac resynchronization therapy
stress induced