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Genotoxic stress impacts pre-mRNA 3'-end processing.

Biswendu BiswasStéphan Vagner
Published in: BioEssays : news and reviews in molecular, cellular and developmental biology (2024)
Genotoxic stress, arising from various environmental sources and endogenous cellular processes, pose a constant threat to genomic stability. Cells have evolved intricate mechanisms to detect and repair DNA damage, orchestrating a robust genotoxic stress response to safeguard the integrity of the genome. Recent research has shed light on the crucial role of co- and post-transcriptional regulatory mechanisms in modulating the cellular response to genotoxic stress. Here we highlight recent advances illustrating the intricate interplay between pre-mRNA processing, with a focus on 3'-end processing, and genotoxic stress response.
Keyphrases
  • dna damage
  • stress induced
  • transcription factor
  • induced apoptosis
  • gene expression
  • oxidative stress
  • signaling pathway
  • risk assessment
  • dna repair
  • climate change
  • endoplasmic reticulum stress
  • human health
  • heat shock