Directing Amphiphilic Self-Assembly: From Microstructure Control to Interfacial Engineering.

The self-assembly of small molecules into complex nanoscale structures is driven by the interplay of various noncovalent interactions. It has now become evident that by maneuvering this intermolecular interaction the geometry and interfacial properties of several nanoscale objects can be tamed. In particular, diverse structures such as spheres, rods, worms, ribbons, and vesicles can be produced by tuning the packing of molecules in the aggregate. Stimuli-sensitive assemblies that can reversibly associate or dissociate in response to environmental changes have been fabricated as model systems for the self-regulated drug delivery vehicle. Surface passivation of inorganic materials can be achieved by the selective organization of molecules at the interface. Such surface functionalization of inorganic materials by organic counterparts provides kinetic stability in biological media and permits the selective binding of active ingredients. Advances made in the area of molecular self-assembly and factors governing such association processes have made it possible to control the interfacial properties and microstructure of nanoscale materials.