Role of low-density lipoprotein receptor rs5925 (1959C>T) gene polymorphism in pathogenesis of dyslipidemia among Egyptian lupus nephritis patients.

Yumn A Alsabbagh Saher A Ahmed Heba E Salama Mai A Abd-Elmawla Hala L Elgendy

Published in: Archives of rheumatology (2022)

C allele is the significantly prevailed LDLR C1959T variant among lupus nephritis patients. Moreover, LDL-R genetic variant may be one of the non-immunological mechanisms implicated in the disturbed lipid profile among lupus nephritis patients. Profound dyslipidemia may partly underscore the deterioration of kidney function among lupus nephritis patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
gene expression
low density lipoprotein
copy number