Renal protection of rhein against 5/6 nephrectomied-induced chronic kidney disease: role of SIRT3-FOXO3α signalling pathway.

Xiaoxiao WuMeiyou LiuGuo WeiYue GuanJialin DuanMiaomiao XiJingwen Wang

Published in: The Journal of pharmacy and pharmacology (2020)

Taken together, rhein protected kidney through SIRT3/FOXO3a involvement. The anti-oxidative capacity of rhein contributed to the protective effects including the subsequent antifibrotic responses.

Keyphrases

chronic kidney disease
transcription factor
oxidative stress
signaling pathway
pi k akt
diabetic rats
end stage renal disease
ischemia reperfusion injury
high glucose
endothelial cells
cell proliferation
stress induced