Rapid determination of phthalates in paper products by supercritical fluid chromatography/tandem mass spectrometry.
Denis V OvchinnikovDanil I FalevPolina V SolovyovaNikolay V Ul'yanovskiiDmitry S KosyakovPublished in: Journal of separation science (2022)
Phthalic acid esters are widely used as components of industrial and consumer products including paper and cardboard packaging materials in contact with food or human skin. Being endocrine-disrupting chemicals, phthalic acid esters have a negative effect on human health and must be controlled in pulp and paper products. In the present study, supercritical fluid chromatography-tandem mass spectrometry in combination with pressurized liquid extraction was proposed for phthalic acid esters determination in such objects. Octadecyl stationary phase with non-endcapped silanol groups ensured rapid (4 min) separation of the 10 priority phthalic acid esters in isocratic elution mode and allowed for effective elimination of interferences from the trace impurities of phthalic acid esters in the mobile phase. The attained limits of quantitation are in the range of 0.7-10 μg/L in extracts and 0.02-0.3 μg/g in paper and cardboard samples. The developed method is distinguished by analysis rapidity, easy sample preparation procedure, high selectivity, low susceptibility to mobile phase contamination with analytes, low cost, and environmental friendliness due to the use of carbon dioxide as a main component of the mobile phase. The method was successfully tested on real samples of toilet paper and food packaging paper and cardboard in which eight analytes were found at the levels of 0.03-43.5 μg/g.
Keyphrases
- tandem mass spectrometry
- liquid chromatography
- ultra high performance liquid chromatography
- human health
- high performance liquid chromatography
- solid phase extraction
- mass spectrometry
- gas chromatography
- simultaneous determination
- risk assessment
- high resolution mass spectrometry
- molecularly imprinted
- liquid chromatography tandem mass spectrometry
- high resolution
- carbon dioxide
- low cost
- heavy metals
- minimally invasive
- health risk
- health information
- social media
- quantum dots