Role of Inositol-Requiring Enzyme 1 and Autophagy in the Pro-Fibrotic Mechanism Underlying Graves' Orbitopathy.

Chae Eun Lee Ji-Young Kim Jin Sook Yoon JaeSang Ko

Published in: Yonsei medical journal (2024)

IRE1 mediates autophagy and the pro-fibrotic mechanism of GO, which provides a more comprehensive interpretation of GO pathogenesis and suggests potential therapeutic targets.

Keyphrases

endoplasmic reticulum stress
cell death
systemic sclerosis
idiopathic pulmonary fibrosis
signaling pathway
anti inflammatory
oxidative stress