Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels.

Hussein N RubaiyTobias SeitzSven HahnAxel ChoidasPeter HabenbergerBert KleblKlaus DinkelPeter NussbaumerHerbert WaldmannMathias ChristmannDavid J Beech

Published in: British journal of pharmacology (2018)

This study has revealed a new tool compound for EA and TRPC1/4/5 channel research, which could be useful for characterizing endogenous TRPC1/4/5 channels and understanding EA-binding sites and their physiological relevance.

Keyphrases

vascular smooth muscle cells
single cell
angiotensin ii