Ankyrin-2 genetic variants: A case of Ankyrin-B syndrome.

Jin Song Bryan Richard SasmitaGuoLan Deng

Published in: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc (2022)

Inherited cardiac arrhythmias (ICA) have become one of the leading causes of sudden cardiac death in people under 40 years old. Variants in the ankyrin-B or ankyrin-2 genes will result in several cardiac arrhythmias ranging from sinus node dysfunction to life-threatening arrhythmias. In this case study, we report a typical ankyrin-2 variant, in which ventricular tachyarrhythmias might be reproduced through exercise or stress tests.

Keyphrases

left ventricular
congenital heart disease
heart failure
physical activity
oxidative stress
high intensity
genome wide
lymph node
copy number
gene expression
stress induced
body composition
catheter ablation