High-Resolution Bisulfite-Sequencing of Peripheral Blood DNA Methylation in Early-Onset and Familial Risk Breast Cancer Patients.

Justin Chen Maria K HaanpääJoshua J GruberNatalie JägerJames M FordMichael P Snyder

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our observations suggest a broader role for DNA methylation in early-onset, familial risk breast cancer. Further studies are warranted to clarify these mechanisms and the benefits of DNA methylation screening for early risk prediction of familial cancers.

Keyphrases

early onset
dna methylation
late onset
genome wide
peripheral blood
high resolution
gene expression
copy number