Trough polymyxin B plasma concentration is an independent risk factor for its nephrotoxicity.

Lu HanFang-Min XuXiao-Shan ZhangChun-Hong ZhangYing DaiZi-Ye ZhouYe-Xuan WangFan ChenDa-Wei ShiGuan-Yang LinXu-Ben Yu

Published in: British journal of clinical pharmacology (2021)

In this study, when the calculated combined predictor value was >6.678, there was an increased risk of AKI. Maintaining a polymyxin B Cmin level below 3.13 mg/L may be helpful in reducing the incidence of polymyxin B associated nephrotoxicity.

Keyphrases

gram negative
acute kidney injury
risk factors
drug induced
multidrug resistant