Bone-marrow mesenchymal stem-cell administration significantly improves outcome after retinal ischemia in rats.
Biji MathewJacqueline N PostonJohn C DreixlerLeianne TorresJasmine LopezRuth ZelkhaIrina BalyasnikovaMaciej S LesniakSteven RothPublished in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2017)
Taken together, our results indicate that intravitreal injection of BMSCs rescued the retina from ischemic damage in a rat model. The mechanisms include suppression of apoptosis, attenuation of inflammation and vascular permeability, and preservation of autophagy.
Keyphrases
- oxidative stress
- diabetic retinopathy
- bone marrow
- mesenchymal stem cells
- ischemia reperfusion injury
- optical coherence tomography
- optic nerve
- endoplasmic reticulum stress
- umbilical cord
- cell death
- endothelial cells
- ultrasound guided
- vascular endothelial growth factor
- cerebral ischemia
- cell cycle arrest
- signaling pathway
- cell therapy
- brain injury
- blood brain barrier
- cell proliferation