Analysis of heart injury laboratory parameters in 273 COVID-19 patients in one hospital in Wuhan, China.
Huan HanLinlin XieRui LiuJie YangFang LiuKailang WuLang ChenWei HouYong FengChengliang ZhuPublished in: Journal of medical virology (2020)
An outbreak of severe acute respiratory syndrome novel coronavirus (SARS-CoV-2) epidemic spreads rapidly worldwide. SARS-CoV-2 infection caused mildly to seriously and fatally respiratory, enteric, cardiovascular, and neurological diseases. In this study, we detected and analyzed the main laboratory indicators related to heart injury, creatine kinase isoenzyme-MB (CK-MB), myohemoglobin (MYO), cardiac troponin I (ultra-TnI), and N-terminal pro-brain natriuretic peptide (NT-proBNP), in 273 patients with COVID-19 and investigated the correlation between heart injury and severity of the disease. It was found that higher concentration in venous blood of CK-MB, MYO, ultra-TnI, and NT-proBNP were associated with the severity and case fatality rate of COVID-19. Careful monitoring of the myocardiac enzyme profiles is of great importance in reducing the complications and mortality in patients with COVID-19.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- coronavirus disease
- heart failure
- protein kinase
- high resolution
- atrial fibrillation
- risk factors
- cardiovascular events
- cardiovascular disease
- type diabetes
- resting state
- adverse drug
- functional connectivity
- multiple sclerosis
- coronary artery disease
- mass spectrometry
- anti inflammatory
- blood brain barrier
- electronic health record