Nebulised recombinant activated factor VII (rFVIIa) does not attenuate the haemorrhagic effects of blast lung injury.

Jason Edward SmithS WattsA M SpearC WilsonE Kirkman

Published in: Journal of the Royal Army Medical Corps (2018)

A single dose of nebulised rFVIIa did not attenuate pulmonary haemorrhage in a rabbit model of blast lung injury. As there was some evidence of systemic absorption, the inhaled route does not avoid the concern about potential thromboembolic complications from administration of rFVIIa.

Keyphrases

pulmonary hypertension
cystic fibrosis
risk factors
atrial fibrillation
human health