Differentiation of low- and high-grade pediatric gliomas with amide proton transfer imaging: added value beyond quantitative relaxation times.

Hongxi ZhangXingwang YongXiaohui MaJianjiang ZhaoZhipeng ShenXinchun ChenFengyu TianWeibo ChenDan WuYi Zhang

Published in: European radiology (2021)

• Amide proton transfer (APT) MRI showed significantly (p < 0.05) higher values in pediatric patients with high-grade gliomas than those with low-grade ones. • The area under the curve was 0.86 for APT MRI to differentiate low-grade and high-grade gliomas in pediatric patients, which was substantially higher than that for quantitative T1 (0.69) and T2 (0.68). • APT MRI demonstrated added value beyond quantitative T1 and T2 mapping in characterizing pediatric gliomas.

Keyphrases

high grade
low grade
high resolution
contrast enhanced
magnetic resonance imaging
diffusion weighted imaging
electron transfer
photodynamic therapy
high density