Immunohistochemistry identifies E-cadherin, N-cadherin and focal adhesion kinase (FAK) as predictors of stage I non-small cell lung carcinoma spread through the air spaces (STAS), and the combinations as prognostic factors.
Yunchang MengYimin WangLeilei LiuRanpu WuQingfeng ZhangZhangxuan ChenYang YaoXinjing LiYanzhuo GongHuijuan LiZhaofeng WangHongbing LiuPublished in: Translational lung cancer research (2024)
E-cadherin, N-cadherin, and FAK are predictors of STAS occurrence in stage I NSCLC, and their combinations are prognostic factors. The discovery of these molecular markers provides clinicians with a reliable means that may help in the early identification of individuals with a higher risk of recurrence in lung cancer patients, targeting personalized treatment plans such as aggressive adjuvant therapy or closer follow-up.
Keyphrases
- prognostic factors
- cell migration
- cell adhesion
- small cell lung cancer
- small molecule
- single cell
- risk assessment
- genome wide
- cell therapy
- palliative care
- high throughput
- health insurance
- stem cells
- advanced non small cell lung cancer
- cancer therapy
- gene expression
- single molecule
- free survival
- combination therapy
- mesenchymal stem cells
- escherichia coli