Gestational exposure to continuous light impairs the development of the female reproductive system in adult Wistar rat offspring.
Fernanda Mithie OgoGlaucia Eloisa Munhoz Lion SiervoAna Maria PraxedesHenrique Rodrigues VieiraSuellen Ribeiro da Silva ScartonAna Tereza Bittencourt GuimarãesArielle Cristina ArenaAndréa Name Colado SimãoMarina Trevizan GuerraPaulo Cezar de Freitas MathiasGlaura Scantamburlo Alves FernandesPublished in: Birth defects research (2023)
Female exposure to continuous light during the intrauterine period resulted in the adult reduction of LH and increased progesterone plasma levels, and uterine injuries a higher number of endometrial glands and reduced levels of antioxidant enzymes, such as glutathione reductase and glutathione S-transferase. In these experimental conditions, gestational continuous light exposure disturbs sex hormone balance and reduces the antioxidant enzymatic activity in the uterus of female offspring in adult life.