Reduction of circulating innate lymphoid cell progenitors results in impaired cytokine production by innate lymphoid cells in patients with lupus nephritis.
Seungwon RyuEun Young LeeDong Ki KimYon Su KimDoo Hyun ChungJi Hyung KimHajeong LeeHye-Young KimPublished in: Arthritis research & therapy (2020)
The percentage of CD117+ ILCs and the capacity of ILCs to secrete cytokines fell as LN severity increased, suggesting that an inflammatory environment of LN induces persistent differentiation and exhaustion of ILCs.