Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts.
Elinor Margrethe Chelsom VogtFrancisco Gómez RealEystein Sverre HusebyeSigridur BjörnsdottirBryndis BenediktsdottirRandi Jacobsen BertelsenPascal DemolyKarl Anders FranklinLeire Sainz de Aja GallasteguiFrancisco Javier Callejas GonzálezJoachim HeinrichMathias HolmNils Oscar JogiBenedicte LeynaertEva LindbergAndrei MalinovschiJesús Martínez-MoratallaRaúl Godoy MayoralAnna OudinAntonio Pereira-VegaChantal Raherison SemjenVivi SchlünssenKai TriebnerMarianne ØksnesPublished in: Endocrine connections (2022)
Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.