Orally Administrable H 2 S-Scavenging Metal-Organic Framework Prepared by Co-Flow Microfluidics for Comprehensive Restoration of Intestinal Milieu.

Intestinal milieu disorders are strongly related to the occurrence of inflammatory bowel diseases (IBDs), which results from mucosa destruction, epithelium disruption and tight junction (TJ) proteins loss. Excess of H 2 S in the intestinal milieu produced by sulfate-reducing bacteria metabolism contributes to IBDs development via epithelial barrier breakdown. Conventional interventions, such as surgery and anti-inflammatory medications, are considered not completely effective because of frequent recurrence and other complications. Herein, a novel oral delivery system, a hydroxypropyl methylcellulose acetate succinate (HPMCAS)-based polymer-coated Zr-based metal-organic framework (UiO-66) with a Cu x -rhodamine B (CR) probe (hereinafter referred to as HUR), was produced via co-flow microfluidic assistance with ability to reduce H 2 S levels, thus restoring the intestinal lumen milieu. HPMCAS serves as an enteric coating that exposes UiO-66@CR at the pH of the intestine but not the acidic pH of the stomach. The synthesized HUR exhibits notable therapeutic efficacy, including mucosa recovery, epithelium integrity restoration and TJ proteins up-regulation via H 2 S scavenging to protect against intestinal barrier damage and microbiome dysbiosis. Thus, HUR has been verified to be a promising theranostic platform able to decrease the H 2 S content for intestinal milieu disorder treatment. The presented study therefore opens the door for further exploitation for IBDs therapy. This article is protected by copyright. All rights reserved.