Investigating the relationship between sleep disturbances and white matter hyperintensities in older adults on the Alzheimer's disease spectrum.

Farooq KamalCassandra MorrisonMahsa Dadar

Published in: medRxiv : the preprint server for health sciences (2023)

These results suggest that WMH burden and sleep disturbance increases from aging to AD. Sleep disturbance decreases cognition through increases in WMH burden. Improved sleep could mitigate the impact of WMH accumulation and cognitive decline.

Keyphrases

cognitive decline
physical activity
mild cognitive impairment
white matter
sleep quality
multiple sclerosis
risk factors