Simulated Microgravity Effects on Human Adenocarcinoma Alveolar Epithelial Cells: Characterization of Morphological, Functional, and Epigenetic Parameters.

Paolo DeganKatia Cortese Alessandra PullieroSilvia BrunoMaria Cristina GaglianiMatteo CongiuAlberto Izzotti

Published in: International journal of molecular sciences (2021)

Our results provide evidence that mitochondria are strongly sensitive to µG. We suggest that mitochondria damage might in turn trigger miRNA modulation related to cell cycle imbalance.

Keyphrases

cell cycle
cell proliferation
endothelial cells
cell death
reactive oxygen species
endoplasmic reticulum
dna methylation
squamous cell carcinoma
gene expression
oxidative stress
induced pluripotent stem cells
sensitive detection
living cells
locally advanced
radiation therapy
quantum dots