Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma.
Alessia ViscontiNiccolò RossiHelena DerišKarla A LeeMaja HanićIrena Trbojević-AkmačićAndrew M ThomasLaura A BolteJohannes R BjörkJahlisa S Hooiveld-NoekenRuth BoardMark HarlandJulia Newton-BishopMark HarriesJoseph J SaccoPaul LoriganHeather M ShawElisabeth G E de VriesRudolf S N FehrmannRinse K WeersmaTim D SpectorPaul NathanGeke A P HospersPeter SasieniVeronique BatailleGordan LaucMario FalchiPublished in: BMC cancer (2023)
While changes in serum protein glycosylation have been previously implicated in a pro-metastatic melanoma behaviour, we show here that they are also associated with response to ICI, opening new avenues for the stratification of patients and the design of adjunct therapies aiming at improving immune response.