Activation of μ-opioid receptors by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its fluorinated derivatives.
Daniel T Baptista-HonMark SmithSamuel SingletonLysbeth H AntonidesNiamh Nic DaéidCraig McKenzieTim G HalesPublished in: British journal of pharmacology (2020)
Fluorinated derivatives of MT-45 are potent μ receptor agonists and this may pose a danger to illicit opioid users. Inhibition of NMDA receptors by a metabolite of MT-45 may contribute to the reported dissociative effects.