Shared epitope defines distinct associations of cigarette smoking with levels of anticitrullinated protein antibody and rheumatoid factor.
Yuki IshikawaKatsunori IkariMotomu HashimotoKoichiro OhmuraMasao TanakaHiromu ItoAtsuo TaniguchiHisashi YamanakaTsuneyo MimoriChikashi C TeraoPublished in: Annals of the rheumatic diseases (2019)
CS confers the risks of high autoantibody levels in RA in different manners; CS interacts with SE alleles on ACPA level, while CS impacts on RF level despite SE allele. These data suggest novel distinct production mechanisms of RF and ACPA.