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Clofazimine inhibits innate immunity against Mycobacterium tuberculosis by NF-κB.

Xinda LiXiaoyi LuoBin WangLei FuXi ChenYu Lu
Published in: mSphere (2024)
(Mtb), the etiologic agent of TB, from TB patients is a complicated process that takes a long time. The excessive immune inflammatory response of the host for a long time causes irreversible organic damage to the lungs and liver. Current antibiotic-based treatment options involve multiple complex drug combinations, often targeting different physiological processes of Mtb. Given the high incidence of post-tuberculosis lung disease, we should also consider the immunomodulatory properties of other drugs when selecting drug combinations.
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