Hydropathic AF-2 variants in the androgen receptor gene among androgen insensitivity patients.

Silvana GiuliattiAnna Flavia Figueredo BenedettiRaquel Martinez RamosReginaldo José PetroliSorahia DomeniceBerenice Bilharinho MendoncaRafael Loch Bastista

Published in: Andrology (2024)

Our study provides valuable insights into AR mutations' phenotypic characteristics and clinical impact on the AF2 region in AIS. Moreover, the disruption of protein dynamics underscores the significance of the AF2 region in AR function and its role in the pathogenesis of AIS.

Keyphrases

atrial fibrillation
end stage renal disease
copy number
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
genome wide
patient reported outcomes
dna methylation
binding protein
protein protein
genome wide analysis