Nebulization is the most widely used respiratory delivery technique with non-invasive properties. However, nebulized drugs often fail to function due to the excretion and immune clearance of the respiratory system. Here, inspired by pollen in nature, novel shell-core aerosol particles (APs) capable of Brownian Motion were constructed for respiratory delivery. Drugs-loaded poly(lactic-co-glycolic acid) nanoparticles were prepared by emulsification to form the inner core, and the membranes of macrophages were extracted to form the outer shell. The optimized size and the shell-core structure endowed APs with Brownian Motion and atomization stability, thus enabling the APs to reach the bronchi and alveoli deeply for effective deposition. The camouflage of macrophage membranes equipped the APs with immune evasion. In vitro experiments proved that deferoxamine (DFO) loaded APs (DFO@APs) could promote the angiogenesis of human umbilical vein endothelial cells. A hyperoxia-induced bronchopulmonary dysplasia (BPD) model was constructed to validate the efficiency of DFO@APs. In BPD mice, DFO@APs could release DFO in the alveolar interstitium, thus promoting the reconstruction of microvasculature, ultimately inducing lung development for treating BPD. In conclusion, this study developed "pollen"-inspired shell-core aerosol particles capable of Brownian Motion, which provides a novel idea and theoretical basis for respiratory administration. This article is protected by copyright. All rights reserved.