Evolution and Current Status of the Multidisciplinary Management of Locally Advanced Rectal Cancer.
Benjamin W DeschnerNoam A VanderWaldeAxel GrotheyDavid ShibataPublished in: JCO oncology practice (2021)
The management of locally advanced rectal cancer has grown in both complexity and quality since the first proctectomy. What once was a malignancy with a fairly consistent treatment algorithm for decades, a recent paradigm shift in the care of these patients has led to a more personalized, multidisciplinary approach with variations in timing, sequence, duration, and potential exclusion of multimodality therapies. This review summarizes the most important evidence behind these developing overarching concepts to provide a context for this paradigm shift.
Keyphrases
- locally advanced
- rectal cancer
- neoadjuvant chemotherapy
- phase ii study
- squamous cell carcinoma
- quality improvement
- radiation therapy
- current status
- end stage renal disease
- ejection fraction
- healthcare
- newly diagnosed
- prognostic factors
- palliative care
- machine learning
- peritoneal dialysis
- risk assessment
- patient reported outcomes
- pain management
- climate change
- lymph node
- chronic pain