Switch/sucrose-non-fermentable (SWI/SNF) complex (SMARCA4, SMARCA2, INI1/SMARCB1)-deficient colorectal carcinomas are strongly associated with microsatellite instability: an incidence study in 4508 colorectal carcinomas.

Mahsa S AhadiTalia L FuchsAdele ClarksonAmy SheenLoretta SiosonAngela ChouAnthony J Gill

Published in: Histopathology (2022)

SWI/SNF complex deficiency is rare in CRC but is enriched in MMRd cases. Identifying these cases has morphological associations and prognostic significance, and in the future may have potential therapeutic implications.

Keyphrases

high grade
risk factors
current status
replacement therapy
genetic diversity
smoking cessation