Progress in the field of noninvasive diagnostics for colorectal cancer: a systematic review for the accuracy of blood-based biomarkers for detection of advanced pre-cancerous lesions.
Rishabh GoyalMolla M WassieJean WinterTimothy J H LathleanGraeme P YoungErin L SymondsPublished in: Expert review of molecular diagnostics (2023)
Many different blood-based biomarkers have been assessed for detection of advanced pre-cancerous lesions, but few have progressed beyond the discovery stage. While some biomarkers have reported high sensitivity and specificity, larger prospective studies in unbiased intended-use screening populations are required for validation.