IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells.

Li Cheng Yang Jiao Wei Jiang Xin Zhang Liping Zhang Gongwei Jia

Published in: Journal of immunology research (2022)

IL-33 deficiency alleviated lung injury in the LPS-induced ARDS model, which was closely related to suppressing Th17 responses and regulating the Th17/Treg balance. The expansion of Th17 cells and imbalance in Th17/Treg cells may be associated with IL-6 and IL-23 secreted from IL-33-activated DCs.

Keyphrases

lps induced
inflammatory response
dendritic cells
induced apoptosis
cell cycle arrest
acute respiratory distress syndrome
oxidative stress
immune response
extracorporeal membrane oxygenation
mechanical ventilation
metabolic syndrome
replacement therapy
skeletal muscle