Inhaled bacteriophage therapy in a porcine model of pneumonia caused by Pseudomonas aeruginosa during mechanical ventilation.

Antoine Guillon Jeoffrey PardessusGuillaume L'HostisCindy FevreCeline BarcEmilie DalloneauYouenn JouanElsa Bodier-MontagutelliYonatan PerezCamille ThoreyLaurent MereghettiMaria CabreraMickaël RiouLaurent VecellioSandrine Le GuellecNathalie Heuzé-Vourc'h

Published in: British journal of pharmacology (2021)

Our findings demonstrated (i) the feasibility of delivering large amounts of active phages by nebulization during mechanical ventilation and (ii) rapid control of in situ infection by inhaled bacteriophage in an experimental model of P. aeruginosa pneumonia with high translational value.

Keyphrases

mechanical ventilation
respiratory failure
cystic fibrosis
pseudomonas aeruginosa
acute respiratory distress syndrome
intensive care unit
extracorporeal membrane oxygenation
biofilm formation
community acquired pneumonia
acinetobacter baumannii
stem cells
staphylococcus aureus