Neurovascular Complications of Iatrogenic Fusarium solani Meningitis.
Nora StrongGrant MeeksSunil A ShethLouise McCulloughJulian A VillalbaChunfeng TanAndrew BarretoAudrey WangerMichelle McDonaldPeter KanHashem ShaltoniJose Campo MaldonadoVictoria ParadaAmeer E HassanSarah Reagan-SteinerTom ChillerJeremy A W GoldDallas J SmithLuis Ostrosky-ZeichnerPublished in: The New England journal of medicine (2024)
A multinational outbreak of nosocomial fusarium meningitis occurred among immunocompetent patients who had undergone surgery with epidural anesthesia in Mexico. The pathogen involved had a high predilection for the brain stem and vertebrobasilar arterial system and was associated with high mortality from vessel injury. Effective treatment options remain limited; in vitro susceptibility testing of the organism suggested that it is resistant to all currently approved antifungal medications in the United States. To highlight the severe complications associated with fusarium infection acquired in this manner, we report data, clinical courses, and outcomes from 13 patients in the outbreak who presented with symptoms after a median delay of 39 days.
Keyphrases
- end stage renal disease
- risk factors
- ejection fraction
- candida albicans
- newly diagnosed
- minimally invasive
- chronic kidney disease
- spinal cord
- prognostic factors
- electronic health record
- machine learning
- spinal cord injury
- escherichia coli
- cystic fibrosis
- big data
- methicillin resistant staphylococcus aureus
- sleep quality
- patient reported outcomes
- physical activity
- blood brain barrier
- pseudomonas aeruginosa
- functional connectivity
- atrial fibrillation
- acinetobacter baumannii
- subarachnoid hemorrhage