Differences in pituitary adenylate cyclase-activating peptide and calcitonin gene-related peptide release in the trigeminovascular system.

Jacob Carl Alexander EdvinssonAnne-Sofie GrellKarin WarfvingeMajid SheykhzadeLars EdvinssonKristian Agmund Haanes

Published in: Cephalalgia : an international journal of headache (2020)

Unlike CGRP, PACAP is only released within the trigeminal ganglion. This raises the question of whether a migraine therapy aimed at preventing peripheral PACAP signalling would be as successful as the CGRP signalling targeted treatments.

Keyphrases

neuropathic pain
signaling pathway
genome wide
copy number
cancer therapy
spinal cord
spinal cord injury
growth hormone
optic nerve
mesenchymal stem cells
bone marrow
smoking cessation