Integrative bioinformatics approach for identifying key genes and potential therapeutic targets in the concurrent manifestation of hypertrophic cardiomyopathy and pulmonary hypertension.
Xi ZhengChenyang ZhangTao YangZhanyang LuoJunyi XiaWeibin TianJuan ShaoHu ZhangJingru GongXuhui BaoPublished in: Journal of thoracic disease (2024)
in their pathogenesis. The identification of six candidate drugs offers a hopeful vista for future therapeutic strategies targeting this complex cardiovascular interplay, marking a significant stride towards mitigating the compounded morbidity of HCM and PH. Future mechanistic and clinical studies are warranted for the investigation of this potential target and therapeutics.
Keyphrases
- hypertrophic cardiomyopathy
- pulmonary hypertension
- left ventricular
- current status
- bioinformatics analysis
- genome wide
- small molecule
- cancer therapy
- pulmonary artery
- pulmonary arterial hypertension
- heart failure
- locally advanced
- squamous cell carcinoma
- radiation therapy
- dna methylation
- network analysis
- risk assessment
- gene expression
- climate change
- rectal cancer