Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water.
Makoto TakenakaMitsuhiro KikkawaTakahiro MatsumotoTakeshi YatabeTatsuya AndoKi-Seok YoonSeiji OgoPublished in: Chemistry, an Asian journal (2018)
Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O2 and in water.