A GWAS follow-up of obesity-related SNPs in SYPL2 reveals sex-specific association with hip circumference.

J de Toro-MartínF GuénardA TchernofY DeshaiesL PérusseS BironO LescelleurL BierthoS MarceauMarie-Claude Vohl

Published in: Obesity science & practice (2016)

This study reveals strong evidence for a novel association between rs9661614 (T>C) and HC in women, which likely reflects a preferential association of SYPL2 to a gynoid profile of fat distribution. The study findings support a clinical significance of SYPL2 worth considering when assessing risk factors associated with obesity.

Keyphrases

metabolic syndrome
type diabetes
weight loss
adipose tissue
body mass index
weight gain
polycystic ovary syndrome
gene expression
pregnant women
physical activity
dna methylation
pregnancy outcomes