Smoking Behavior and Prognosis After Colorectal Cancer Diagnosis: A Pooled Analysis of 11 Studies.
Elizabeth AlwersPrudence R CarrBarbara BanburyViola WalterJenny Chang-ClaudeLina JansenDavid A DrewEdward L GiovannucciHongmei NanSonja I BerndtWen-Yi HuangAnna E PrizmentRichard B HayesLori C SakodaEmily WhiteJulia D LabadieMartha SlatteryRobert E SchoenBrenda DiergaardeBethany Van GuelpenPeter T CampbellUlrike PetersAndrew T ChanPolly A NewcombMichael HoffmeisterHermann BrennerPublished in: JNCI cancer spectrum (2021)
This large consortium of CRC patient studies provides compelling evidence that smoking is strongly associated with worse survival of stage I-III CRC patients in a clear dose-response manner. The detrimental effect of smoking was primarily related to noncolorectal cancer events, but current heavy smoking also showed an association with CRC-specific survival.