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Life course effects of genetic susceptibility to higher body size on body fat and lean mass: prospective cohort study.

Scott WaterfieldTom G RichardsonGeorge Davey SmithLinda M O'KeeffeJoshua A Bell
Published in: International journal of epidemiology (2023)
Genetic variants for body size are more strongly associated with adiposity than with lean mass. Sex-combined childhood variants are more strongly associated with increased adiposity until early adulthood. This may inform future studies that use genetics to investigate the causes and impact of adiposity at different life stages.
Keyphrases
  • insulin resistance
  • weight gain
  • copy number
  • early life
  • bone mineral density
  • depressive symptoms
  • current status
  • adipose tissue
  • genome wide
  • dna methylation