HIV/HBV coinfection remodels the immune landscape and natural killer cell ADCC functional responses.
Bo SunKelly A S da CostaAljawharah AlrubayyiJonida KokiciNatasha Fisher-PearsonNoshin HussainStefano D'AnnaLorenzo PiermatteoRomina SalpiniValentina SvicherStephanie KucykowiczIndrajit GhoshFiona M BurnsSabine KinlochPedro SimoesSanjay BhaganiPatrick T F KennedyMala K MainiRachael J M Bashford-RogersUpkar S GillDimitra PeppaPublished in: Hepatology (Baltimore, Md.) (2024)
This study provides new insights into the differential signature and functional profile of NK cells in HBV and HIV/HBV coinfection, highlighting pathways that can be manipulated to tailor NK cell-focused approaches to advance HBV cure strategies in different patient groups.