Optimization of the antimicrobial peptide Bac7 by deep mutational scanning.

Philipp KochSteven SchmittAlexander HeynischAnja GumpingerIrene WüthrichMarina GysinDimitri ShcherbakovSven N HobbieSven PankeMartin Held

Published in: BMC biology (2022)

We demonstrated that the presented platform can be used to establish the sequence-activity relationship of antimicrobial peptides, and showed its usefulness for hit-to-lead identification and optimization of antimicrobial drug candidates.

Keyphrases

staphylococcus aureus
high resolution
high throughput
electron microscopy
emergency department
adverse drug