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BRD3-NUTM1-expressing NUT carcinoma of lung on endobronchial ultrasound-guided transbronchial needle aspiration cytology, a diagnostic pitfall.

Sameer Chhetri AryalShereen ZiaShannon RodgersYulei ShenKyle PerryLisi Yuan
Published in: Diagnostic cytopathology (2021)
When a specimen demonstrates a dual cell population of squamoid cells and primitive-looking tumor cells in the wrong clinical context (i.e., young patient with no smoking history), further molecular profiling is warranted to include the differential of a primary NC of the lung. The cytological features of NC itself have rarely been documented and moreover, that of a primary NC of the lung with BRD3-NUTM1 fusion has never been reported. We herein report cytological findings of a primary NC of the lung with BRD3-NUTM1 fusion gene.
Keyphrases
  • ultrasound guided
  • fine needle aspiration
  • induced apoptosis
  • gene expression
  • genome wide
  • copy number
  • bone marrow
  • cell death
  • cell therapy
  • oxidative stress
  • single molecule
  • cell cycle arrest